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Coformycin

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Coformycin og 2'-deoxycoformycin (pentostatin) er to naturligt forekommende antitumor antibiotika, som hæmmer enzymet adenosin deaminase meget kraftigt. Hæmmerkonstanterne ligger mellem 10-11 og 10-13 M. Forbindelserne er isoleret fra bakterien Streptomyces antibioticus.

Coformycin MV= 284,27 g/mol

Deoxycoformycin MV= 268,27 g/mol

Strukturerne af coformycin og deoxycoformycin

Hong. M., and Hosmane, R.S. 1997. Irreversible, thight-binding inhibition of adenosine deaminase by coformycins: inhibitor structural features that contribute to the mode of enzyme inhibition. Nucleosides and nucleotides. 16:1053-1057; Hosmane, R.S. and Hong, M. 1997. How important is the N-3 sugar moiety in the thight-binding interaction of coformycin and adenosine deaminase. Biochemical and Biophysical Research Communications. 236:88-93; Marrone et al. 1996. Theoretical study of inhibition of adenosine deaminase by (8R)-coformycin and (8R)-deoxycoformycin. J. Med. Chem. 39:277-284

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