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Methioninsulfoximid

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Andre navne: Methioninsulfoximin; 2-amino-4-(Smethylsulfonimidosyl)butansyre; L-S-(3-amino-3-carboxypropyl)-S-methylsulfoximin. (Eng.: Methionine sulfoximine)

Methioninsulfoximid er et derivat af aminosyren methionin. Methioninsulfoximid er fundet i brd bagt af mel der er behandlet med melblegningsmidlet nitrogentrichlorid. Methioninsulfoximid og dens analoger hmmer enzymet glutaminsyntetase hvorved syntesen af aminosyren glutamin forstyrres, da glutamin er en neurotransmitter kan det forklare hvorfor methioninsulfoximid kan inducere kramper (Griffith and Meister 1978).

MV= 180,23 g/mol; SMP> 210oC (dec.); bruttoformel: C5H12N2O3S; CAS-nummer: 15985-39-4 (L-formen)

Strukturen af aminosyren methioninsulfoximid

K73, Challenger, F. 1953. The biological importance of organic compounds of sulphur. Endeavour. 12:173-181 (E576); Griffith, O.W. and Meister, A. 1978. Differential inhibition of glutamine and γ-glutamylcysteine synthetases by α-alkyl analogs of methionine sulfoximine that induce convulsions. The Journal of Biological Chemistry. 253:2333-2338 (6832); (6833)

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