Lactisole

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Synonyms: Lactisol, 2-(4-methoxyphenoxy)propanoic acid

Lactisole is an antagonist to sweet-tasting compounds as sugars (e.g. sucrose), sweet-tasting proteins (e.g. thaumatin) and artificial sweeteners (e.g. cyclamate) (Jiang, P. et al.).

MW= 196.2 g/mol; MP= 90 ^o C; BP= 173-175 ^o C; bruttoformula: C₁₀H₁₂O₄; CAS-number: 13794-15-5;

Lactisole

3D structure of lactisole

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Jiang, P., Cui, M., Zhao, B., Liu, Z., Snyder, L.A., Benard, L.M.J., Osman, R., Margolskee, R.F., Max, M. 2005. Lactisole interacts with the transmembrane domains of human T1R3 to inhibit sweet taste. The Journal of Biological Chemistry. 280(15), 15238-15246

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